Haemato-Oncology Products

AsparPeg

(Peg L Asparaginase 3750 IU / 5ml)

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Product Description

AsparPeg is L-asparaginase (L-Amidohydrolase) that is covalently conjugated to monomethoxypolyethelene glycol (mPEG). L-Asparaginase is a tetrameric enzyme that is endogenously by E. coli and consists of identical 34.5 kDa subunits. Approximately 69 to 82 molecules of mPEG are linked to L-asparaginase; the molecular weight of each mPEG molecule is about 5kDa. The mechanism of action of Peg Asparaginase is thought to be based on selective killing of leukemic cells due to depletion of plasma asparagine.

Indications :

  • Indicated as a component of multi agent chemotherapeutic regimen for the treatment of patients for Acute Lymphoblastic Leukemia who are hypersensitive to asparaginase

Storage

  • Store at 2 to 8°C
  • Protect from light
  • Do not freeze or shake

Shelf-life

24 months from the date of manufacturing

Avangio

(Bevacizumab -100mg/4ml & 400mg/4ml)

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Product Description

Avangio is a recombinant humanized monoclonal IgG1 antibody that binds to and inhibits the biologic activity of human vascular endothelial growth factor (VEGF). Avangio contains human framework regions and the complementarity-determining regions of a murine antibody that binds to VEGF. Avangio is produced in a Chinese Hamster Ovary mammalian cell expression system in a nutrient medium and has a molecular weight of approximately 149kDa.

Indications

  • Metastatic colorectal cancer (MCRC)
  • Non-squamous non-small cell lung cancer (NSCLC) )
  • Recurrent Glioblastoma (GBM) )
  • Metastatic renal cell carcinoma (mRCC) )
  • Persistent, recurrent, or metastatic cervical cancer (CC) )

Storage

  • Store at 2 to 8°C
  • Protect from light
  • Do not freeze

Shelf-life

24 months from the date of manufacturing

Mobixafor

(Plerixafor 24mg/ 1.2ml)

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Product Description

Mobixafor is a bicyclam derivative, a selective reversible antagonist of the CXCR4 chemokine receptor and blocks binding of its cognate ligand, stromal cell-derived factor-1 (SDF-1), also known as CXCL 12. Mobixafor-induced leucocytosis and elevations in circulating hematopoietic progenitor cell levels are thought to result from a disruption of CXCR4 binding to its cognate ligand, resulting in the appearance of both; mature and pluripotent cells in the systemic circulation. CD34+ cells mobilized by Mobixafor are functional and capable of engraftment with long-term repopulating capabilities.

Indications

  • Adult patients – Mobixafor is indicated in combination with granulocyte-colony stimulating factor (G-CSF) to enhance mobilisation of haematopoietic stem cells to the peripheral blood for collection and subsequent autologous transplantation in adult patients with lymphoma or multiple myeloma whose cells mobilise poorly
  • Paediatric patients (1 to less than 18 years) – Mobixafor is indicated in combination with G-CSF to enhance mobilisation of haematopoietic stem cells to the peripheral blood for collection and subsequent autologous transplantation in children with lymphoma or solid malignant tumours, either:
  • -> Pre-emptively, when circulating stem cell count on the predicted day of collection after adequate mobilization with G-CSF (with or without chemotherapy) is expected to be insufficient with regards to desired hematopoietic stem cells yield, or

    -> Who previously failed to collect enough haematopoietic stem cells

Storage

  • Store at 25°C, excursions permitted to 15-30°C

Shelf-life

36 months from the date of manufacturing

Ritulasta

(Rituximab -100mg/10ml & 500mg/50 ml)

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Product Description

Ritulasta is a genetically engineered chimeric murine/human monoclonal antibody directed against the CD20 antigen found on the surface of normal and malignant B lymphocytes. The antibody is an IgG1 kappa immunoglobulin containing murine light and heavy-chain variable region sequences and human constant region sequences. Ritulasta is composed of two heavy chains of 451 amino acids and two light chains of 231 amino acids.

Indications

  • Non-Hodgkin's lymphoma
  • Chronic lymphocytic leukemia
  • Rheumatoid Arthritis
  • Granulomatosis with Polyangiitis (GPA) and Microscopic Polyangiitis.

Storage

  • Store at 2 to 8°C
  • Protect from light
  • Do not freeze

Shelf-life

30 months from the date of manufacturing